Table 6.
90% CI test of pharmacokinetic parameters after logarithmic conversion in healthy subjects after oral administration of globalagliatin 80 mg
| Parameter | Geometric mean (high-fat meal, N = 24) | Geometric mean (fasting, N = 24) | Ratio % (high-fat meal/fasting) | 90% CI |
|---|---|---|---|---|
| Cmax (ng/mL) | 26.60 | 21.31 | 124.81 | 109.97–141.65 |
| AUCt (h*ng/mL) | 917.50 | 678.44 | 135.24 | 124.24–147.20 |
| AUC∞ (h*ng/mL) | 973.57 | 718.93 | 135.42 | 124.42–147.39 |
CI confidence interval, Cmax maximum concentration, AUCt area under the plasma concentration-time curve from time zero to time of the last quantifiable concentration, AUC∞ area under the plasma concentration-time curve from time zero extrapolated to infinity