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. 2024 Apr 22;14:9181. doi: 10.1038/s41598-024-58845-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacological profiles of (9S)-HHC, (9R)-HHC, and Δ⁹-THC. (A) Calculated maximum response values or the time-course peaks were plotted on the axes of the radar plot. For clathrin-mediated internalization (CME), the 60 min time points were used; for ERK1/2 phosphorylation, the 10 min time points were used. (B) Calculated maximum response values of the tested cannabinoids were represented as fractions of WIN and normalized to (9R)-HHC. The normalized values for β-arrestin interaction were plotted on the x-axis, and the means of the normalized values for G_i1/G_oA activation were plotted on the y-axis. The values represent only the maximum responses elicited by the ligands.