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. 2024 Apr 22;14:9177. doi: 10.1038/s41598-024-59834-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Normal iPSCs and NPCs properties in cells generated by 2 Gaucher disease patients. (a) Schematic representation of a three-steps neuronal differentiation protocol starting from iPSCs (left), NPCs (middle) and iPSCs-derived neuronal cells (Right) with corresponding protein marker expression. (b) Bright field images of iPSCs colonies in Control (left), GD3-1 (middle) and GD3-2 (right) samples. (c) (Left) TRA-1–60 and Hoechst fluorescence in control, GD3-1 and GD3-2 iPSCs groups. (Right) Summary of TRA-1–60 positive cells detected by flow cytometry in control, GD3-1 and GD3-2 iPSCs groups (Kruskal–Wallis test: H(2) = 1.07, p = 0.66, n = 3 technical replicates). (d) Bright field images of NPCs in Control (left), GD3-1 (middle) and GD3-2 (right) samples. (e) (Left) PAX6 and Hoechst fluorescence in control, GD3-1 and GD3-2 iPSCs groups. (Right) Summary of PAX6 positive cells detected by flow cytometry in control, GD3-1 and GD3-2 iPSCs groups (Kruskal–Wallis test: H(2) = 0.84, p = 0.70, n = 3 technical replicates).