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Targeted therapy resistance in NSCLC. The image shows the mechanisms of the main targets that generate resistance in targeted therapy for NSCLC. The above eight targets generate drug resistance through gene mutation(mut), activation(act), amplification(amp), or fusion(fus). Mutated targets have been marked in black. In particular, mutations in PTEN, an inhibitor of PI3K, also lead to tumor progression. Created with BioRender.com.
