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. 2024 Apr 9;15:1383494. doi: 10.3389/fneur.2024.1383494

Figure 3.

Figure 3

Infarct growth depends on ischemia duration. (A–C) Infarct growth after tMCAO in rodents without neuroprotective treatment. (A) Infarct growth between MRI 1 and MRI 2 based on the duration of ischemia. Each dot represents the mean infarct growth in an individual study. (B) Estimated infarct growth per hour based on the duration of ischemia. Each dot represents an individual study. Assuming a linear growth of infarct volume within the first 48 h, the expected infarct growth per hour can be calculated for ischemia durations between 0 and 2 h using the following formula: 1.62 × t (t: duration of ischemia in hours; t < = 2). This formula is limited to ischemic times between 0 and 2 h. We assume that the curve flattens and is no longer linear with longer ischemic durations, but we cannot estimate this from our available data. (C) Each cross represents the change in mean infarct volumes in an individual study. The median change in mean infarct volumes was 48% after 30–60 min ischemia duration, 76% after 90–95 min ischemia duration and 89% after > = 120 min ischemia duration. (D) Infarct growth after tMCAO in rodents with neuroprotective treatment. Each cross represents the change in mean infarct volumes in an individual study. The median change in mean infarct volumes was-16% after 30–60 min ischemia duration, 32% after 90–95 min ischemia duration and 21% after > = 120 min ischemia duration. (E,F) Infarct growth based on ischemia duration in human stroke patients. (E) Infarct growth between MRI 1 and MRI 2 based on the duration of ischemia. Each dot represents the infarct growth of an individual patient. (F) Assuming a linear growth of infarct volume within the first 48 h, the expected infarct growth per hour can be calculated for ischemia durations between 0 and 2 h using the following formula: 0.26 × t (t: duration of ischemia in hours; t < = 16). This formula is limited to ischemic times between 0 and 16 h. We assume that the curve flattens and is no longer linear with longer ischemic durations, but we cannot estimate this from our available data.