Table 2.
Trends of therapeutic drugs prescribed in outpatients with migraine between 2018 and 2022
| 2018 | 2019 | 2020 | 2021 | 2022 | Total | P1 | P2 | |
|---|---|---|---|---|---|---|---|---|
| Total therapeutic drugs | 1882 | 2096 | 1699 | 2010 | 2237 | 9924 | 0.133 | – |
| Analgesics | 1228 (65.25) | 1404 (66.98) | 1218 (71.69) | 1427 (71.00) | 1693 (75.68) | 6970 (70.23) | 0.221 | < 0.001 |
| NSAIDs | 461 (24.50) | 477 (22.76) | 514 (30.25) | 561 (27.91) | 769 (34.38) | 2782 (28.03) | 0.028 | < 0.001 |
| Ibuprofen | 161 (8.55) | 158 (7.54) | 181 (10.65) | 189 (9.40) | 321 (14.35) | 1010 (10.18) | 0.086 | < 0.001 |
| loxoprofen | 67 (3.56) | 64 (3.05) | 86 (5.06) | 69 (3.43) | 107 (4.78) | 393 (3.96) | 0.221 | < 0.001 |
| Celecoxib | 45 (2.39) | 63 (3.01) | 70 (4.12) | 87 (4.33) | 92 (4.11) | 357 (3.60) | 0.028 | < 0.001 |
| Caffeine-containing agents | 372 (19.77) | 422 (20.13) | 379 (22.31) | 469 (23.33) | 556 (24.85) | 2198 (22.15) | 0.086 | < 0.001 |
| Opioids | 298 (15.83) | 388 (18.51) | 267 (15.72) | 338 (16.82) | 297 (13.28) | 1588 (16.00) | 0.807 | 0.004 |
| Codeine/Ibuprofen | 192 (10.20) | 236 (11.26) | 174 (10.24) | 217 (10.80) | 200 (8.94) | 1019 (10.27) | 1.000 | 0.123 |
| Dihydrocodeine/acetaminophen | 30 (1.59) | 67 (3.20) | 23 (1.35) | 49 (2.44) | 43 (1.92) | 212 (2.14) | 1.000 | 0.797 |
| Acetaminophen | 38 (2.02) | 46 (2.19) | 25 (1.47) | 29 (1.44) | 46 (2.06) | 184 (1.85) | 1.000 | 0.516 |
| CPMs | 59 (3.13) | 71 (3.39) | 33 (1.94) | 30 (1.49) | 25 (1.12) | 218 (2.20) | 0.086 | < 0.001 |
| Migraine-specific agents | 585 (31.08) | 604 (28.82) | 424 (24.96) | 526 (26.17) | 482 (21.55) | 2621 (26.41) | 0.462 | < 0.001 |
| Triptans | 556 (29.54) | 604 (28.82) | 424 (24.96) | 526 (26.17) | 482 (21.55) | 2592 (26.12) | 0.462 | < 0.001 |
| Rizatriptan | 331 (17.59) | 414 (19.75) | 288 (16.95) | 379 (18.86) | 349 (15.60) | 1761 (17.74) | 1.000 | 0.045 |
| zolmitriptan | 197 (10.47) | 190 (9.06) | 136 (8.00) | 147 (7.31) | 133 (5.95) | 803 (8.09) | 0.086 | < 0.001 |
| Ergotamine | 29 (1.54) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 29 (0.29) | 0.289 | < 0.001 |
| Antiemetics | 69 (3.67) | 88 (4.20) | 57 (3.35) | 57 (2.84) | 62 (2.77) | 333 (3.36) | 0.613 | 0.011 |
NSAIDs nonsteroidal anti-inflammatory drugs, CPMs Chinese patent medicines. P1, P value for the trend in number of prescriptions, assessed by the Mann-Kendall trend test; P2, P value for the trend in proportion of prescriptions, assessed by the Cochran-Armitage trend test. The number of total therapeutic drugs for each year is the denominator of the data in that column