. 2024 Apr 3;9(4):e00803-23. doi: 10.1128/msphere.00803-23

TABLE 5.

Within- and among-module hubs in the network^a

Focused			Specificity to disease level 1		Network scores				BLAST top-hit results
Index	Module	OTU ID	Score	FDR	Degree	Betweenness	Within-module degree	Module connectivity	Scientific name	Query cover (%)	E value	Identity (%)	Accession
Within	Module 2 (positive)	Bac_00011	3.104	0.0013	13	0.018	1.907	0.663	Pseudomonas izuensis	100	9.0E−123	100.0	OR841525.1
		Bac_00057	2.741	0.0063	6	0.002	1.387	0.000	Massilia violaceinigra	100	9.0E−123	100.0	MT373681.1
		Bac_00002	4.652	<0.0001	10	0.019	0.347	0.720	Arthrobacter globiformis	100	9.0E−123	100.0	OR780585.1
	Module 6 (positive)	Bac_00258	7.205	<0.0001	14	0.011	2.587	0.357	Thermanaerothrix daxensis	100	4.0E−76	88.6	NR_117865.1
		Bac_00182	6.787	<0.0001	21	0.037	1.788	0.649	Brevitalea aridisoli	100	9.0E−93	92.7	NR_151987.1
		Arc_004	6.089	<0.0001	19	0.027	1.388	0.742	Nitrosotenuis chungbukensis	100	9.0E−123	100.0	CP130341.1
	Module 8 (positive)	Bac_00138	7.904	<0.0001	20	0.023	1.595	0.715	Ectothiorhodospira mobilis	100	4.0E−86	91.0	MG264243.1
		Bac_00260	5.320	<0.0001	9	0.006	1.595	0.346	Crenobacter cavernae	100	4.0E−96	93.5	CP031337.1
		Bac_00171	9.499	<0.0001	11	0.012	1.063	0.628	Membranihabitans marinus	100	9.0E−88	91.4	OL441066.1
	Module 1 (negative)	Bac_00014	−4.481	<0.0001	22	0.025	3.676	0.000	Gemmatimonas phototrophica	100	2.0E−89	91.8	CP011454.1
		Bac_00055	−5.245	<0.0001	18	0.015	2.752	0.000	Microbispora rosea	100	9.0E−123	100.0	MN826183.1
		Fun_0033	−1.088	0.1752	17	0.026	2.521	0.000	Trichoderma atroviride	100	9.0E−123	100.0	MN429074.1
	Module 7 (negative)	Bac_00045	−1.380	0.1103	17	0.017	2.356	0.304	Pseudolabrys taiwanensis	100	9.0E−113	97.6	CP031417.1
		Bac_00116	−3.636	0.0003	13	0.006	2.071	0.000	Streptomyces spinosirectus	100	9.0E−123	100.0	CP090447.1
		Bac_00218	−5.182	<0.0001	13	0.010	1.502	0.260	Dyella ginsengisoli	100	9.0E−123	100.0	KY228986.1
Among	Module 2 (positive)	Bac_00039	−1.782	0.0537	11	0.027	0.347	0.744	Arenimonas daechungensis	100	4.0E−116	98.4	NR_109442.1
		Bac_00002	4.652	<0.0001	10	0.019	0.347	0.720	Arthrobacter globiformis	100	9.0E−123	100.0	OR780585.1
		Bac_00469	6.307	<0.0001	5	0.001	−1.214	0.720	Luteitalea pratensis	100	9.0E−108	96.3	NR_156918.1
	Module 6 (positive)	Fun_4447	7.151	<0.0001	10	0.017	−0.610	0.780	Plectosphaerella cucumerina	100	2.0E−108	100.0	MT529301.1
		Fun_3979	5.139	<0.0001	6	0.008	−1.409	0.778	Enterocarpus grenotii	100	8.0E−113	99.6	OU989357.1
		Arc_004	6.089	<0.0001	19	0.027	1.388	0.742	Nitrosotenuis chungbukensis	100	9.0E−123	100.0	CP130341.1
	Module 8 (positive)	Bac_00138	7.904	<0.0001	20	0.023	1.595	0.715	Ectothiorhodospira mobilis	100	4.0E−86	91.0	MG264243.1
		Bac_00180	2.213	0.0224	10	0.008	0.000	0.700	Rubrobacter spartanus	100	4.0E−66	86.3	NR_158052.1
		Fun_4070	8.282	<0.0001	10	0.006	−0.532	0.700	Mortierella kuhlmanii	100	9.0E−53	84.5	MH860115.1
	Module 1 (negative)	Fun_0043	0.485	0.3420	7	0.008	−0.714	0.735	Curvularia senegalensis	100	9.0E−123	100.0	MT476857.1
		Fun_3610	1.694	0.0649	12	0.014	−0.714	0.708	Acremonium alternatum	100	2.0E−118	100.0	MT529342.1
		Bac_00042	1.601	0.0774	12	0.020	−0.252	0.625	Fulvivirgaceae bacterium	100	9.0E−108	96.3	OQ733332.1
	Module 7 (negative)	Fun_0027	2.861	0.0040	5	0.004	−1.059	0.640	Trichoderma virens	100	9.0E−123	100.0	MT530036.1
		Bac_00032	−1.253	0.1331	4	0.001	−1.059	0.625	Streptomyces cyaneus	100	9.0E−123	100.0	OR807486.1
		Bac_00070	2.191	0.0242	4	0.005	−1.059	0.625	Luteimonas aestuarii	100	9.0E−123	100.0	OQ255277.1

^{^a}

In each of the modules highlighted in Table 4 and Fig. 6, the top 3 OTUs with the highest within-module degree (z-standardized) or among-module connectivity are shown. See Data S3 for the full results.