TABLE 1.
Influenza A virus subtype specificities and H-2Kd restriction of CTL clones
| Target cells | Virus used for infection | % Specific 51Cr releasea
|
||
|---|---|---|---|---|
| A-12 | F-4 | B7-B7 | ||
| Expt 1 | ||||
| P815 | A/PR/8 | 37.7 | −6.6 | 66.1 |
| A/Jap | 6.7 | 56.4 | 72.1 | |
| None | 5.9 | 14.5 | −5.2 | |
| Ld-L929 (H-2Ld) | A/PR/8 | 1.1 | 1.7 | 2.4 |
| A/Jap | −4.2 | −1.7 | 2.1 | |
| None | 1.8 | 1.8 | 1.3 | |
| Dd-L929 (H-2Dd) | A/PR/8 | 1.4 | 6.3 | 0.6 |
| A/Jap | −2.5 | −0.6 | −0.3 | |
| None | −8.6 | 0.4 | −2.5 | |
| L929 | A/PR/8 | −0.6 | 0.9 | 21.0 |
| A/Jap | −2.4 | −4.4 | 14.7 | |
| None | −4.1 | −3.0 | 15.6 | |
| Expt 2 | ||||
| CV-K10 (H-2Kd) | A/PR/8 | 37.5 | −0.1 | 31.8 |
| A/Jap | 6.4 | 28.1 | 34.9 | |
| None | 2.3 | 0.8 | 1.8 | |
| CV1 | A/PR/8 | −0.7 | −0.5 | −1.1 |
| A/Jap | 3.6 | 2.5 | −0.5 | |
| None | −1.8 | −1.7 | −0.4 | |
a
The effector-to-target cell ratio was 5:1 in a 4-h assay.