Table 5.
Patient-level measures of diagnostic accuracy for statistically optimal cut-offs and range of possible cut-offs with minimum specificities per segment of 85 to 100%.
| Total study population (N = 144) | Patients with cranial manifestations (N = 117) | Patients without high/very high CVR (N = 90) | Patients with high/very high CVR (N = 54) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sensitivity (95% CI) | Specificity (95% CI) | Correctly classified (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Correctly classified (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Correctly classified (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Correctly classified (95% CI) | |
| Statistically optimal cut-offs | 86.5% (76.9–92.5%) | 81.4% (70.8–88.8%) | 84.0% (77.2–89.1%) | 92.1% (82.7–96.6%) | 87% (75.6–93.6%) | 89.7% (82.9–94.0%) | 89.6% (77.8–95.5%) | 90.5% (77.9–96.2%) | 90.0% (82.1–94.5%) | 80.8% (62.1–91.5%) | 67.9% (49.3–82.1%) | 74.1% (61.1–83.9%) |
| Specificity 85% | 86.5% (76.9–92.5%) | 75.7% (64.5–84.2%) | 81.2% (74.1–86.8%) | 92.1% (82.7–96.6%) | 79.6% (67.1–88.2%) | 86.3% (78.9–91.4%) | 89.6% (77.8–95.5%) | 85.7% (72.2–93.3%) | 87.8% (79.4–93.0%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 86% | 86.5% (76.9–92.5%) | 75.7% (64.5–84.2%) | 81.2% (74.1–86.8%) | 92.1% (82.7–96.6%) | 79.6% (67.1–88.2%) | 86.3% (78.9–91.4%) | 89.6% (77.8–95.5%) | 85.7% (72.2–93.3%) | 87.8% (79.4–93.0%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 87% | 86.5% (76.9–92.5%) | 77.1% (66.0–85.4%) | 81.9% (74.9–87.4%) | 92.1% (82.7–96.6%) | 81.5% (69.2–89.6%) | 87.2% (79.9–92.1%) | 89.6% (77.8–95.5%) | 88.1% (75.0–94.8%) | 88.9% (80.7–93.9%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 88% | 86.5% (76.9–92.5%) | 77.1% (66.0–85.4%) | 81.9% (74.9–87.4%) | 92.1% (82.7–96.6%) | 81.5% (69.2–89.6%) | 87.2% (79.9–92.1%) | 89.6% (77.8–95.5%) | 88.1% (75.0–94.8%) | 88.9% (80.7–93.9%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 89% | 86.5% (76.9–92.5%) | 77.1% (66.0–85.4%) | 81.9% (74.9–87.4%) | 92.1% (82.7–96.6%) | 81.5% (69.2–89.6%) | 87.2% (79.9–92.1%) | 89.6% (77.8–95.5%) | 88.1% (75.0–94.8%) | 88.9% (80.7–93.9%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 90% | 86.5% (76.9–92.5%) | 78.6% (67.6–86.6%) | 82.6% (75.6–88.0%) | 92.1% (82.7–96.6%) | 81.5% (69.2–89.6%) | 87.2% (79.9–92.1%) | 89.6% (77.8–95.5%) | 90.5% (77.9–96.2%) | 90.0% (82.1–94.6%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 91% | 86.5% (76.9–92.5%) | 80.0% (69.2–87.7%) | 83.3% (76.4–88.5%) | 92.1% (82.7–96.6%) | 83.3% (71.3–91.0%) | 88.0% (80.9–92.7%) | 89.6% (77.8–95.5%) | 92.9% (81.0–97.5%) | 91.1% (83.4–95.4%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 92% | 85.1% (75.3–91.5%) | 80.0% (69.2–87.7%) | 82.6% (75.6–88.0%) | 92.1% (82.7–96.6%) | 83.3% (71.3–91.0%) | 88.0% (80.9–92.7%) | 87.5% (75.3–94.1%) | 92.9% (81.0–97.5%) | 90.0% (82.1–94.6%) | 80.8% (62.1–91.5%) | 60.7% (42.4–76.4%) | 70.4% (57.2–80.9%) |
| Specificity 93% | 85.1% (75.3–91.5%) | 85.7% (75.7–92.1%) | 85.4% (78.7–90.3%) | 92.1% (82.7–96.6%) | 90.7% (80.1–96.0%) | 91.5% (85.0–95.3%) | 87.5% (75.3–94.1%) | 95.2% (84.2–98.7%) | 91.1% (83.4–95.4%) | 80.8% (62.1–91.5%) | 71.4% (52.9–84.7%) | 75.9% (63.1–85.4%) |
| Specificity 94% | 83.8% (73.8–90.5%) | 85.7% (75.7–92.1%) | 84.7% (78.0–89.7%) | 92.1% (82.7–96.6%) | 90.7% (80.1–96.0%) | 91.5% (85.0–95.3%) | 87.5% (75.3–94.1%) | 95.2% (84.2–98.7%) | 91.1% (83.4–95.4%) | 76.9% (57.9–89.0%) | 71.4% (52.9–84.7%) | 74.1% (61.1–83.9%) |
| Specificity 95% | 81.1% (70.7–88.4%) | 85.7% (75.7–92.1%) | 83.3% (76.4–88.5%) | 88.9% (78.8–94.5%) | 90.7% (80.1–96.0%) | 89.7% (82.9–94.0%) | 83.3% (70.4–91.3%) | 95.2% (84.2–98.7%) | 88.9% (80.7–93.9%) | 76.9% (57.9–89.0%) | 71.4% (52.9–84.7%) | 74.1% (61.1–83.9%) |
| Specificity 96% | 79.7% (69.2–87.3%) | 90.0% (80.8–95.1%) | 84.7% (78.0–89.7%) | 87.3% (76.9–93.4%) | 94.4% (84.9–98.1%) | 90.6% (83.9–94.7%) | 83.3% (70.4–91.3%) | 97.6% (87.7–99.6%) | 90.0% (82.1–94.6%) | 73.1% (53.9–86.3%) | 78.6% (60.5–89.8%) | 75.9% (63.1–85.4%) |
| Specificity 97% | 77.0% (66.3–85.1%) | 91.4% (82.5–96.0%) | 84.0% (77.2–89.1%) | 84.1% (73.2–91.1%) | 94.4% (84.9–98.1%) | 88.9% (81.9–93.4%) | 79.2% (65.7–88.3%) | 97.6% (87.7–99.6%) | 87.8% (79.4–93.0%) | 73.1% (53.9–86.3%) | 82.1% (64.4–92.1%) | 77.8% (65.1–86.8%) |
| Specificity 98% | 73.0% (61.9–81.8%) | 94.3% (86.2–97.8%) | 83.3% (76.4–88.5%) | 79.4% (67.8–87.5%) | 96.3% (87.5–99.0%) | 87.2% (79.9–92.1%) | 72.9% (59.0–83.4%) | 97.6% (87.7–99.6%) | 84.4% (75.6–90.5%) | 73.1% (53.9–86.3%) | 89.3% (72.8–96.3%) | 81.5% (69.2–89.6%) |
| Specificity 99% | 68.9% (57.7–78.3%) | 98.6% (92.3–99.7%) | 83.3% (76.4–88.5%) | 74.6% (62.7–83.7%) | 98.1% (90.2–99.7%) | 85.5% (78.0–90.7%) | 68.8% (54.7–80.1%) | 100% (91.6–100%) | 83.3% (74.3–89.6%) | 69.2% (50.0–83.5%) | 96.4% (82.3–99.4%) | 83.3% (71.3–91.0%) |
| Specificity 100% | 63.5% (52.1–73.6%) | 100% (94.8–100%) | 81.2% (74.1–86.8%) | 68.3% (56.0–78.4%) | 100% (93.4–100%) | 82.9% (75.1–88.7%) | 62.5% (48.4–74.8%) | 100% (91.6–100%) | 80.0% (70.6–87.0%) | 65.4% (46.2–80.6%) | 100% (87.9–100%) | 83.3% (71.3–91.0%) |
GCA, giant cell arteritis; CI, confidence interval; CVR, cardiovascular risk; N, number of patients in the subpopulation.