FIG. 1.

Identification of linear epitopes from PrP protein fragment phage display libraries. Three linear epitopes, designated I, II, and III, were identified by panning the PrP fragment libraries against recombinant Fab fragments applied to ELISA wells. Sequence alignments of clones taken following two or three rounds of panning are shown below the corresponding mouse PrP amino acid sequence. Regions of commonality are underlined. (A) Fab R10; (B) Fab D4; (C) Fab D13; (D) Fab R72; (E) Fab R1; (F) Fab R2.