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. Author manuscript; available in PMC: 2024 Apr 23.
Published in final edited form as: Nat Neurosci. 2023 Jul 31;26(9):1529–1540. doi: 10.1038/s41593-023-01397-2

Extended Data Fig. 8. Activation of VTA Dat+ neurons and DR Sert+ neurons in HW-treated mice.

Extended Data Fig. 8.

a, Schematic injection of AAV-DIO-ChR2 in VTA of Dat-Cre female HW animals. b, Percentage sucrose water consumption in SPT. **P = 0.0029, two-tailed Mann-Whitney test. c, Immobility time in TST. **P = 0.0041, two-tailed Mann-Whitney test. d, Immobility time in FST. **P = 0.0035, two-tailed Mann-Whitney test. e, Percentage time spent in open arms in EPM. P = 0.6737, two-tailed Mann-Whitney test. f, Percentage time spent in the center in OFT. P = 0.8945, two-tailed Mann-Whitney test. g, Pup grooming time. **P = 0.0082, two-tailed Mann-Whitney test. h, Social preference index in the three-chamber sociability test. **P = 0.0012, two-tailed Mann-Whitney test. b-h, n = 7 mice in each group, mean ± s.d. i-p, Similar to a-h but for photo-activation of DR Sert+ neurons. n = 7 mice in each group, Mean ± s.d. Statistics: P = 0.40214 (j), ***P = 0.0006 (k), **P = 0.0012 (l), *P = 0.0437 (m), ***P = 0.0006 (n), ***P = 0.0006 (o), ***P = 0.0006 (p), two-tailed Mann-Whitney test..