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. 2024 Apr 23;28(8):e18122. doi: 10.1111/jcmm.18122

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© 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Immunohistochemistry findings in a VWA1‐patient derived muscle biopsy. (A) Immunostaining of CD20 revealed cells in capillaries and vessels within the muscle tissue in addition to reactivity in few circulating cells. (B) Increased immunoreactivity of MUM1⁺ cells in muscular capillaries and vessels in addition to immunoreactivity in few circulating cells. (C) CD138 immunostaining showed a reactivity of singular cells in muscular capillaries and vessels as well as in few circulating cells. (D) CRP staining revealed a pronounced immunoreactivity in the thickened connective tissue in addition to immunoreactivity in big, foamy, rounded cells (most likely macrophages).