TABLE 2.
List of proteins significantly dysregulated in VWA1‐patient derived plasma. Protein functions were extracted from UniProt (www.uniprot.org).
| UniProt accession # | Protein name | Number of unique peptides identified | Ratio patient/control | p‐value | Function |
|---|---|---|---|---|---|
| Increased proteins | |||||
| P68871 | Haemoglobin subunit beta (HBB) | 7 | 7.41 | 0.000009 | Functions as an endogenous inhibitor of enkephalin‐degrading enzymes |
| P00915 | Carbonic anhydrase 1 (CA1) | 8 | 6.94 | 0.000197 | Catalyses the reversible hydration of carbon dioxide |
| P69905 | Haemoglobin subunit alpha (HBA) | 8 | 6.70 | 0.000017 | Involved in oxygen transport from the lung to the various peripheral tissues |
| P32119 | Peroxiredoxin‐2 (PRDX2) | 5 | 6.59 | 0.000029 | Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide‐mediated signalling events |
| P02042 | Haemoglobin subunit delta (HBD) | 4 | 5.82 | 0.000038 | Involved in oxygen transport from the lung to the various peripheral tissues |
| P01861 | Immunoglobulin heavy constant gamma 4 (IGHG4) | 6 | 3.14 | 0.000003 | Constant region of immunoglobulin heavy chains |
| P04040 | Catalase (CATA) | 5 | 2,80 | 0,000628 | Protects cells from the toxic effects of hydrogen peroxide and promotes growth of cells including T‐cells and B‐cells |
| P00918 | Carbonic anhydrase 2 (CA2) | 2 | 2,73 | 0.000423 | Catalyses the reversible hydration of carbon dioxide |
| P02741 | C‐reactive protein (CRP) | 4 | 2,46 | 0.011229 | Promotes phagocytosis and complement fixation through its calcium‐dependent binding to phosphorylcholine |
| P02775 | Platelet basic protein (CXCL7) | 5 | 2,20 | 0.000051 | Stimulates mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan |
| P07996 | Thrombospondin‐1 (TSP1) | 15 | 2,01 | 0.000002 | Mediates cell‐to‐cell and cell‐to‐matrix interactions |
| Decreased proteins | |||||
| P00738 | Haptoglobin (HPT) | 11 | 0.52 | 0.000000 | Captures, and combines with free plasma haemoglobin to allow hepatic recycling of heme iron |
| A0A0C4DH38 | Immunoglobulin heavy variable 5–51 (HV551) | 2 | 0.52 | 0.000002 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition |
| A0A0B4J1Y8 | Immunoglobulin lambda variable 9–49 (LV949) | 2 | 0.49 | 0.000001 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition |
| P01717 | Immunoglobulin lambda variable 3–25 (LV325) | 2 | 0.47 | 0.004457 | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition |