TABLE 2.
Molecular characterization of lymphomas
| Virus and animal no. | Tumor tissuea | Latency (days) | DNA rearrange- ments
|
Tumor typeb | Eco- tropicc | c-mycd | |||
|---|---|---|---|---|---|---|---|---|---|
| J1 | J2 | IgH | Igκ | ||||||
| Akv | |||||||||
| 1 | L | 273 | − | − | + | + | B | + | − |
| 2 | S | 366 | − | − | + | + | B | + | − |
| 3 | S | 366 | + | + | + | + | T, Be | + | − |
| 4 | L | 429 | − | − | + | + | B | + | − |
| 5 | L | 491 | − | − | + | + | B | + | − |
| 6 | S, L | 509 | − | − | + | + | B | + | − |
| 7 | S | 593 | − | − | + | + | B | + | − |
| 8 | L | 211 | − | − | + | + | B | + | − |
| 9 | L | 243 | − | − | + | + | B | + | − |
| 10 | L | 245 | − | − | + | + | B | + | − |
| 11 | S | 260 | − | − | + | + | B | + | − |
| Akv1- 99 | |||||||||
| 1 | L | 183 | − | − | + | + | B | + | − |
| 2 | S, L | 197 | + | − | + | + | T, Bf | + | − |
| 3 | L | 204 | − | − | + | − | preB | + | − |
| 4 | L | 252 | − | − | + | + | B | + | − |
| 5 | Sc, S | 293 | − | − | + | + | B | + | − |
| 6 | S, L | 306 | − | − | + | + | B | + | − |
| 7 | L | 310 | − | − | − | − | Nullf | + | − |
| 8 | S, L | 310 | − | − | + | + | B | + | − |
| 9 | L | 349 | + | − | + | + | T, Bg | + | − |
| 10 | L | 495 | + | + | − | − | T | − | + |
| 11 | Sc | 359 | − | − | + | + | B | + | − |
| 12 | S | 359 | − | − | + | + | B | − | − |
| 13 | S | 730 | − | − | + | + | B | + | − |
a
L, Lymphoma; S, spleen; Sc, subcutaneous tumor.
b
Tumor types as determined by hybridization analysis.
c
Southern blot detection of hybridization to an ecotropic-specific probe.
d
Southern blot hybridization of c-myc promoter rearrangement.
e
Mixed T- and B-cell lymphoma as determined by histopathology.
f
Follicular center cell lymphoma as determined by histopathology.
g
Large-cell lymphoblastic lymphoma as determined by histopathology.