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. 1988 Oct;27(3):228–232. doi: 10.1007/BF00205444

Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma

P Weynants 1, P Wauters 2, P G Coulie 3, B Van Den Eynde 2, M Symann 2, T Boon 2
PMCID: PMC11038709  PMID: 2846175

Abstract

Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with inferferon γ, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.

Keywords: Carcinoma, Tumor Cell, Cancer Research, Interferon, Cell Response

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