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. 2024 Apr 23;14:9354. doi: 10.1038/s41598-024-59444-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fluconazole-antibiotic synergism in the reduction of dual-species biofilms formed by Pseudomonas-Candida. Effect of fluconazole (0.5–64 µg/mL) and antibiotics (cefotaxime, ciprofloxacin, gentamicin, meropenem, tetracycline at 0.5–128 µg/mL) on dual-species biofilms. The dual-species biofilms (24 h old) were treated with different combinations of fluconazole and antibiotics. The synograms represent the OD_595nm values as read after 24 h of treatment and the mean reduction percentage of treatment from three independent replicates.