FIG. 1.

Recognition of epitope S-598-605 (RCQIFANI) but not wild-type (CSLWNGPHL) or variant (CSLWSGPHL, CSLWNRPHL, and ECFWNGPHL) S-510-518 epitopes in mice infected with variant virus. Lymphocytes harvested from the brains of mice with acute encephalitis were used in direct ex vivo cytotoxicity assays. Only peptide S-598-605 sensitized EL-4 cells for lysis above the background level (uncoated EL-4 cells [NONE]). Each peptide was analyzed in 3 to 14 independent experiments. The mean percent specific lysis for all experiments is shown. Bars show standard errors.