. 2024 Mar 11;13(5):1223–1237. doi: 10.1007/s40123-024-00919-w

Table 2.

Intra-group clinical outcomes

Characteristics^a	Control group	P	Treatment group	P
OSDI	43.46 ± 21.54 [10.41 to 97.91]	39.83 ± 19.44 [12.50 to 95.83]	0.041^{c, d}	42.71 ± 21.43 [12.50 to 90]	27.85 ± 14.7 [6.3 to 58.33]	< 0.001^{c, d}
SANDE	62.95 ± 17.7 [24.5 to 100]	59.25 ± 17.7 [10 to 98.9]	< 0.001^{c, d}	68.15 ± 22 [8.94 to 100]	39.82 ± 22.57 [8.94 to 88]	< 0.001^{b, d}
TMH (mm)	0.19 ± 0.54 [0.08 to 0.28]	0.20 ± 0.47 [0.10 to 0.28]	0.104^c	0.20 ± 0.48 [0.13 to 0.32]	0.21 ± 0.44 [0.12 to 0.30]	0.297^c
TMA (mm²)	2.10 ± 0.51 [0.70 to 2.89]	2.0 ± 0.53 [0.88 to 3.55]	0.198^c	2.1 ± 0.56 [1.1 to 3.15]	2.2 ± 0.61 [1.0 to 3.10]	0.174^c
F-NIBUT (s)	5.12 ± 4.98 [0.10 to 16.73]	5.5 ± 4.59 [0.35 to 16.28]	0.069^b	5.97 ± 7.32 [0.06 to 20.53]	7.43 ± 6.86 [0.07 to 19.74]	< 0.001^{b, d}
A-NIBUT (s)	7.60 ± 4.60 [1.54 to 18]	8.10 ± 4.16 [2.56 to 18.6]	0.066^b	7.9 ± 6.84 [0.17 to 21]	9.78 ± 6.2 [0.33 to 20.87]	< 0.001^{b, d}
LLG	2.63 ± 0.93 [1 to 4]	2.97 ± 0.76 [2 to 4]	0.002^{c, d}	2.32 ± 0.66 [1 to 4]	3.02 ± 0.51 [2 to 4]	< 0.001^{b, d}
U-LAMG (%)	41.23 ± 20.54 [14 to 97]	42.73 ± 19.65 [18 to 99]	0.083^c	41.87 ± 17.47 [10 to 89]	39.97 ± 17.1 [17 to 89]	0.071^c
L-LAMG (%)	51.13 ± 20.36 [25 to 89]	52.53 ± 18.9 [20 to 91]	0.228^b	58.58 ± 19.87 [13 to 90]	56.7 ± 18.73 [25 to 92]	0.098^c
U-MGD grade	1.7 ± 0.65 [1 to 3]	1.63 ± 0.72 [1 to 3]	0.414^b	1.85 ± 0.58 [1 to 3]	1.75 ± 0.63 [1 to 3]	0.102^b
L-MGD grade	2.03 ± 0.76 [1 to 3]	1.9 ± 0.84 [1 to 3]	0.102^c	2.38 ± 0.63 [1 to 3]	2.3 ± 0.65 [1 to 3]	0.180^c
MGYSS	19.97 ± 7.58 [6 to 36]	20 ± 7.35 [6 to 34]	0.880^c	19.02 ± 7.96 [4 to 40]	26.6 ± 6.23 [15 to 40]	< 0.001^{c, d}
MGYLS	7.2 ± 3.59 [4 to 15]	7.7 ± 3.63 [2 to 15]	0.060^c	5.73 ± 4.17 [0 to 15]	10.43 ± 3 [5 to 15]	< 0.001^{b, d}
MGYCS	1.1 ± 1.65 [0 to 6]	1.3 ± 1.34 [0 to 4]	0.198^b	1.27 ± 2.04 [0 to 10]	2.88 ± 2 [0 to 10]	< 0.001^{b, d}
NCIH (%)	9.4 ± 5.8 [1.6 to 34.5]	8.5 ± 3.9 [1.7 to 22]	0.125^b	8.8 ± 4 [4.3 to 22.1]	8.4 ± 3.1 [3.50 to 18.60]	0.167^b
TCIH (%)	8.5 ± 3.6 [2.6 to 15.5]	8.2 ± 3.5 [1.6 to 16.3]	0.309^c	9.3 ± 3.4 [3.9 to 17.3]	9.5 ± 2.8 [4.4 to 14.7]	0.518^c
NCOH (%)	10.1 ± 5.56 [2.9 to 31.1]	9.4 ± 4.28 [3.4 to 25.6]	0.214^b	10.81 ± 3.2 [6.4 to 20.4]	10.33 ± 2.65 [5.1 to 18.3]	0.199^b
TCOH (%)	8.97 ± 2.3 [4.3 to 16.3]	8.87 ± 2.74 [4.2 to 14.6]	0.704^c	11.1 ± 3.24 [6.1 to 18.70]	10.5 ± 2.8 [5.3 to 16]	0.223^c
OSS	2.23 ± 0.89 [1 to 4]	1.87 ± 1 [0 to 3]	0.027^{b, d}	2.1 ± 0.81 [1 to 4]	1.4 ± 0.9 [0 to 3]	< 0.001^{b, d}

Characteristics^a

Control group

Treatment group

Baseline

Last visit
(8th week)

Baseline

Last visit
(8th week)

OSDI

43.46 ± 21.54

[10.41 to 97.91]

39.83 ± 19.44

[12.50 to 95.83]

0.041^{c, d}

42.71 ± 21.43

[12.50 to 90]

27.85 ± 14.7

[6.3 to 58.33]

< 0.001^{c, d}

SANDE

62.95 ± 17.7

[24.5 to 100]

59.25 ± 17.7

[10 to 98.9]

< 0.001^{c, d}

68.15 ± 22

[8.94 to 100]

39.82 ± 22.57

[8.94 to 88]

< 0.001^{b, d}

TMH (mm)

0.19 ± 0.54

[0.08 to 0.28]

0.20 ± 0.47

[0.10 to 0.28]

0.104^c

0.20 ± 0.48

[0.13 to 0.32]

0.21 ± 0.44

[0.12 to 0.30]

0.297^c

TMA (mm²)

2.10 ± 0.51

[0.70 to 2.89]

2.0 ± 0.53

[0.88 to 3.55]

0.198^c

2.1 ± 0.56

[1.1 to 3.15]

2.2 ± 0.61

[1.0 to 3.10]

0.174^c

F-NIBUT (s)

5.12 ± 4.98

[0.10 to 16.73]

5.5 ± 4.59

[0.35 to 16.28]

0.069^b

5.97 ± 7.32

[0.06 to 20.53]

7.43 ± 6.86

[0.07 to 19.74]

< 0.001^{b, d}

A-NIBUT (s)

7.60 ± 4.60

[1.54 to 18]

8.10 ± 4.16

[2.56 to 18.6]

0.066^b

7.9 ± 6.84

[0.17 to 21]

9.78 ± 6.2

[0.33 to 20.87]

< 0.001^{b, d}

LLG

2.63 ± 0.93

[1 to 4]

2.97 ± 0.76

[2 to 4]

0.002^{c, d}

2.32 ± 0.66

[1 to 4]

3.02 ± 0.51

[2 to 4]

< 0.001^{b, d}

U-LAMG (%)

41.23 ± 20.54

[14 to 97]

42.73 ± 19.65

[18 to 99]

0.083^c

41.87 ± 17.47

[10 to 89]

39.97 ± 17.1

[17 to 89]

0.071^c

L-LAMG (%)

51.13 ± 20.36

[25 to 89]

52.53 ± 18.9

[20 to 91]

0.228^b

58.58 ± 19.87

[13 to 90]

56.7 ± 18.73

[25 to 92]

0.098^c

U-MGD grade

1.7 ± 0.65

[1 to 3]

1.63 ± 0.72

[1 to 3]

0.414^b

1.85 ± 0.58

[1 to 3]

1.75 ± 0.63

[1 to 3]

0.102^b

L-MGD grade

2.03 ± 0.76

[1 to 3]

1.9 ± 0.84

[1 to 3]

0.102^c

2.38 ± 0.63

[1 to 3]

2.3 ± 0.65

[1 to 3]

0.180^c

MGYSS

19.97 ± 7.58

[6 to 36]

20 ± 7.35

[6 to 34]

0.880^c

19.02 ± 7.96

[4 to 40]

26.6 ± 6.23

[15 to 40]

< 0.001^{c, d}

MGYLS

7.2 ± 3.59

[4 to 15]

7.7 ± 3.63

[2 to 15]

0.060^c

5.73 ± 4.17

[0 to 15]

10.43 ± 3

[5 to 15]

< 0.001^{b, d}

MGYCS

1.1 ± 1.65

[0 to 6]

1.3 ± 1.34

[0 to 4]

0.198^b

1.27 ± 2.04

[0 to 10]

2.88 ± 2

[0 to 10]

< 0.001^{b, d}

NCIH (%)

9.4 ± 5.8

[1.6 to 34.5]

8.5 ± 3.9

[1.7 to 22]

0.125^b

8.8 ± 4

[4.3 to 22.1]

8.4 ± 3.1

[3.50 to 18.60]

0.167^b

TCIH (%)

8.5 ± 3.6

[2.6 to 15.5]

8.2 ± 3.5

[1.6 to 16.3]

0.309^c

9.3 ± 3.4

[3.9 to 17.3]

9.5 ± 2.8

[4.4 to 14.7]

0.518^c

NCOH (%)

10.1 ± 5.56

[2.9 to 31.1]

9.4 ± 4.28

[3.4 to 25.6]

0.214^b

10.81 ± 3.2

[6.4 to 20.4]

10.33 ± 2.65

[5.1 to 18.3]

0.199^b

TCOH (%)

8.97 ± 2.3

[4.3 to 16.3]

8.87 ± 2.74

[4.2 to 14.6]

0.704^c

11.1 ± 3.24

[6.1 to 18.70]

10.5 ± 2.8

[5.3 to 16]

0.223^c

OSS

2.23 ± 0.89

[1 to 4]

1.87 ± 1

[0 to 3]

0.027^{b, d}

2.1 ± 0.81

[1 to 4]

1.4 ± 0.9

[0 to 3]

< 0.001^{b, d}