Table 1.

Cytotoxicity assessment of EPMC in HepG2 and A549 cells, and evaluation of EPMC's anti-DENV-2 activities.

Cell	MNTD80 (μM) ± SD	CC50 (μM) ± SD	EC50 (μM) ± SD	SI
HepG2	602.68 ± 56.54	731.51 ± 38.85	22.58 ± 3.67	32.40
A549	851.61 ± 99.00	1070.13 ± 51.86	6.17 ± 0.28	173.44

The maximum-non-toxic dose (MNTD₈₀) is the dose at which 80% of the cells remain viable, while the half-maximal cytotoxicity concentration (CC₅₀) is the concentration at which 50% of the cell viability is reduced. The half-maximal effective concentration (EC₅₀) refers to the concentration of EPMC required to inhibit viral progeny by 50%. The selectivity index (SI) was calculated as the ratio of EPMC's cytotoxicity to its antiviral activity (CC₅₀/EC₅₀). Data were acquired from three independent experiments and presented as mean ± SD.