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. 2024 Apr 23;7:491. doi: 10.1038/s42003-024-06077-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–d Ionic current values were retrieved via the f5c eventalign software. Current variations were evaluated in parallel for forward (blue) and reverse (orange) strands and computed at each M13mp18 genomic position across the 525 bp fragments containing randomly incorporated rCMPs as the sum of the absolute values of the differences between the current distributions of each “rC” sample respect to the “DNA-only” internal control. a Comparison between the two DNA-only replicates. b–d Comparison between “DNA-only” and b “rC 400 μM”, c “rC 600 μM” and d “rC 800 μM”. e The same data distributions were summarised as a box plot grouped for comparison and strand. Statistical analyses were performed by two-way ANOVA (N = 517 genomic positions, comparison: F = 52.08, df = 3, P = 4.92e−33; strand: F = 6.08, df = 1, P = 1.37e−02; comparison/strand interaction: F = 7.73, df = 3, P = 3.77e−05). The box plot shows the median as a solid black line, the first and third quartiles captured by the boundaries of the box, and whiskers defined as the first and third quartiles ± interquartile range 1.5 times.