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. 2024 Apr 23;7:489. doi: 10.1038/s42003-024-06121-9

Fig. 2. siRNAs mechanism of action.

Fig. 2

After the internalization of nanoparticles (1), siRNAs are released from the endosome (2) and loaded into the RNA-induced silencing complex (RISC) (3). The siRNAs are then incorporated into RISC, leading to the cleavage of the sense strand (4). The antisense strand (guide strand) binds to its target mRNA (5), and the siRNA guide strand bound to RNA induces an endonucleolytic cleavage mediated by the protein Argonaute-2 (Ago2), which prevents mRNA translation (6). Created with BioRender.com (Agreement number: ZF26ML06W7).