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Circular dichroism spectra. Far-UV circular dichroism spectra for individual proteins (H3: orange, MeCP2 variant: red), and the complex (black). The additive effect of the individual spectra is shown in gray. The spectra for full-length MeCP2 (A and B) are shown, as well as the spectra for MBD (C and D). The interaction of the MeCP2 variants was tested with H3 (A and C) and H3K27me3 (B and D). The corresponding near-UV spectra are shown as inset accompanying the far-UV spectra.
