Figure 1.

The four primary components of the proposed research framework.

The first block is identifying the sub-stages using multimodal data such as genetics, structural magnetic resonance images, neuronal signals, or connectivity matrix. The second block is the model framework using the state space model for extracting the features namely the state and causality changes. The extracted features will be fed in the third block for the individualized prediction and finally therapeutic option depicted in the fourth block. Created with Inkscape software.