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Drug candidates targeting Aβ and/or tau or facilitating degradation via the ALP.
The drugs listed in the three circles are currently in clinical trials. The molecular tweezer CLR01 (Shahpasand-Kroner et al., 2023) in the middle has been shown preclinically to target all three mechanisms. Created using Adobe Illustrator. Aβ: Amyloid-β; ALP: autophagy-lysosomal pathway.
