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. 2024 Feb 21;11(16):2308009. doi: 10.1002/advs.202308009

Figure 7.

Figure 7

Overexpression of RECQL4 in HCC is associated with poor prognosis. A) RECQL4 expression levels in 976 cases of HCC and non‐tumor tissues from four independent cohorts (FDUZS, TCGA‐LIHC, ICGC‐LIRI‐JP, and GSE14520). B,C) Representative images and statistical analysis of RECQL4 IHC staining intensity in 240 pairs of tissues. Scale bar, 50 µm. D) Kaplan‐Meier RFS curve of HCC tissues with high and low RECQL4 levels in FDUZS cohort (n = 159). E–G) Kaplan‐Meier OS curves of HCC tissues with high and low RECQL4 levels in three independent cohorts (TCGA‐LIHC cohort, n = 349; ICGC‐LIRI‐JP cohort, n = 243; GSE14520 cohort, n = 225). H) Meta‐analysis model integrating OS prognostic analysis results from three independent cohorts. I,J) Kaplan‐Meier OS and DFS curves of HCC tissues with high and low RECQL4 IHC‐score after quantifying IHC staining intensity (FDUZS cohort, n = 240). * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.