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. Author manuscript; available in PMC: 2024 Apr 24.
Published in final edited form as: J Am Coll Cardiol. 2023 Jan 31;81(4):374–389. doi: 10.1016/j.jacc.2022.10.037

CENTRAL ILLUSTRATION. Treatment Effects of Different Antithrombotic Strategies in the Fontan Circulation.

CENTRAL ILLUSTRATION

Treatment effects of aspirin, warfarin, and nonvitamin K oral anticoagulants (NOACs) were compared using no thromboprophylaxis as a reference in a bivariate analysis. Incidence rate ratios (IRRs) of thromboembolic events (TEs) are reported on the y-axis and IRRs of major bleeding (MB) on x-axis. No thromboprophylaxis as a reference has a neutral effect on TE and MB, which equals 1 on the x- and y-axes. NOAC were associated with the greatest reduction in thromboembolic events, yet the greatest risk of major bleeding. Aspirin tended to have the most favorable overall profile, with both a significantly reduced risk of thromboembolic events and a tendency toward lower risk of MB.