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Replication of wild-type (squares) and vpr-deficient (triangles) HIV-1YU-2 in spreading infections of nondividing and dividing cells. PBMCs (A [PBMC-1] and B [PBMC-2]), MDMs (D [MDM-1], E [MDM-2], and F [MDM-3]), primary MG (G [MG-4] and H [MG-5]), and CEM-CCR5 cells (C) were challenged with normalized virus stocks produced by transfection of 293T cells. Virus production, and hence replication, was measured as the expression of soluble p24gag in the culture supernatants.
