| Central hypotonia |
|
| Cerebral |
Cerebral palsy, Spinal cord injuries, Cerebral dysgenesis, Intracranial hemorrhage, Hypoxic-ischemic encephalopathy, Congenital cytogenetic abnormalities, Chiari malformation |
| Genetic |
Prader-Willi syndrome, Angelman syndrome, Nemaline myopathy, Congenital hypothyroidism, Hypoglycemia, Congenital adrenal hyperplasia |
| Chromosomal |
Down syndrome, Edwards syndrome (Trisomy 18), Patau syndrome (Trisomy 13) |
| Inborn errors of metabolism |
Tay-Sachs, Congenital disorders of glycosylation, Carnitine cycle defects, Fatty acid oxidation defects, Disorders of creatine metabolism, Glycogen storage diseases, Organic acidemias, Peroxisomal disorders, Urea cycle defects |
| Infections |
Bacterial sepsis (urinary tract infection/pyelonephritis, bacteremia, meningitis, pneumonia, cellulitis, gastroenteritis, septic arthritis, osteomyelitis), Botulism, Viral illness (Herpes simplex virus, Enterovirus, Cytomegalovirus, Bronchiolitis, Influenza) |
| Toxins |
Environmental (carbon monoxide, methemoglobinemia), Drug exposure (heroin, cocaine, phencyclidine, marijuana) |
| Peripheral and muscular hypotonia |
|
| Anterior horn cell disorders (motor neurons) |
Acute infantile spinal muscular atrophy, Traumatic myelopathy, Hypoxic-ischemic myelopathy, Arthrogryposis multiplex congenita |
| Congenital motor or sensory neuropathies |
Charcot-Marie-Tooth disease, Familial dysautonomia, Infantile neuroaxonal degeneration, Congenital hypomyelination neuropathy, Dejerine-Sottas disease, Hereditary sensory and autonomic neuropathy |
| Neuromuscular junction disorders |
Transient-acquired neonatal myasthenia, Congenital myasthenia, Magnesium toxicity, Aminoglycoside toxicity |
| Skeletal muscle |
Duchenne and Becker muscular dystrophy, Classic form of congenital muscular dystrophy, Congenital form of congenital muscular dystrophy (Walker-Warburg disease, Muscle-eye-brain disease, Fukuyama disease), Early infantile facioscapulohumeral dystrophy, Congenital myotonic dystrophy |
