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. Author manuscript; available in PMC: 2024 Apr 24.
Published in final edited form as: Science. 2015 Aug 6;349(6249):739–742. doi: 10.1126/science.aab3920

Fig. 1. Clinical parameters of infected NHPs.

Fig. 1.

(A) Platelet counts of infected NHPs in EDTA blood at every examination day. Concentrations of aspartate aminotransferase (AST) (B), alanine transaminase (ALT) (C), and alkaline phosphatase (ALP) (D) were determined in serum samples collected on examination days (d) after EBOV-Makona challenge. U, units. Two-way analysis of variance (ANOVA) with Tukey multiple comparison post test was used to determine statistical significance at the level of 0.05 (*) and 0.0001 (****) for data presented in (B) to (D). Error bars indicate SD. (E) Viremia (titers) for individual animals on examination days and time of euthanasia. TCID50, median tissure culture infectious dose. (F) Survival curves showing outcome of the different vaccine groups after challenge. Statistical significance was assessed by using the Kaplan-Meier method.