Fig. 3. Serum cytokine and chemokine levels of NHPs.
Kinetics of IL-1β, IL-6, IL-15, IFN-γ, IL-10, and MCP-1 were analyzed in serum samples of each animal collected on examination days and time of euthanasia. The dotted line in each panel marks the assay detection limit. Terminal values for the control animal euthanized on day 5 were added to the day-6 time point in this group; similarly, the day-9 time point in the control and day-3 vaccination groups represents all values, including terminal samples obtained from NHPs euthanized on days 7 and 8. BL indicates baseline (before vaccination).