Fig. 1.

Inflamed (left) and non-inflamed tumors respond differently to immune checkpoint blockade therapy. Inflamed tumors contain more T cells, antigen presenting cells and inflammatory M1 macrophages compared to non-inflamed tumors. In non-inflamed tumors, T cells are mainly present at the tumor border and have difficulties infiltrating into the tumor. These are also characterized by more tumor-suppressing immune cells such as M2-macrophages and T-regulatory cells and high abundance of collagen produced by fibroblasts and cancer-associated fibroblasts