Table 2.
Homozygosity blocks identified through homozygosity mapping in proband and related family cohort as well as case–control (all probands vs. related/unrelated family members) cohorts.
| Family ID | Number of homozygous blocks | Number of genes in them | SUDs genes in homozygous blocks | Chromosomes that carry SUDs genes |
|---|---|---|---|---|
| 1 | 6 | 161 | CHRNA4, CNR2 | 20, 1 |
| 2 | 1 | 74 | – | – |
| 3 | 8 | 248 | GABBR1, NPAS4 | 6, 11 |
| 4 | 2 | 62 | – | – |
| 5 | 7 | 187 | DRD4 | 11 |
| Case–Control | 47 | 47 | – | – |