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. 2023 Feb 13;2(2):174–191. doi: 10.1038/s44161-023-00214-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, qPCR of Kdm8 normalized to Rpl13a on 2-month-old control (Kdm8^fl/fl) and mutant (Kdm8^fl/fl;Myh6-Cre or Kdm8^fl/fl;Nkx2-5-Cre) hearts. Error bars denote the mean + /- s.e.m. Data was analyzed by two-way ANOVA. n = 5 hearts per group. The experiment was repeated twice with similar results. b, Hearts of control and mutant mice at 2, 6, 20, and 30 months of age. Scale bar, 1 mm. c, Sections of 2, 6 and 30-month-old control and mutant hearts stained with H&E. Scale bar, 1 mm. d, Echocardiogram analysis of left ventricle (LV) ejection fraction, fractional shortening, diameter at end-systole and end-diastole, and isovolumetric relaxation time normalized to the time between heartbeats (IVRT/RR) in control and mutant mice. Error bars denote the mean + /- s.e.m. Data was analyzed by 2-way ANOVA with Sidak’s multiple comparison correction. n = 10 – 11 mice at 2, 4 and 6 months, n = 5 controls and 7 mutants at 20 months, and n = 3 controls and 4 mutants at end point (EP) (see Supplementary Table 2 for P values). * P < 0.05, ** P < 0.01, *** P < 0.001. e, Survival curve of control, and mutant mice analyzed by Log-rank (Mantel-Cox) test. n = 5 control mice and 9 mutants.

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