Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 13;2(2):174–191. doi: 10.1038/s44161-023-00214-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 2 — a, Echocardiogram analysis of left ventricle (LV) anterior wall thickness at end-diastole, LV posterior wall thickness at end-systole, LV posterior wall thickness at end-diastole, and LV fractional shortening in control (Kdm8^fl/fl), heterozygous (Kdm8^fl/+;Myh6-Cre), and mutant (Kdm8^fl/fl;Myh6-Cre) mice at 2, 4 and 6 months of age. Error bars denote the mean + /- s.e.m. Data was analyzed by 2-way ANOVA with Tuckey’s multiple comparison correction. * denotes comparisons between control and mutants, # between control and heterozygous hearts. n = 6 - 11 mice per group. b, Wheat germ agglutinin staining (WGA) on cross sections of the hearts of 2 and 6-month-old control and mutant mice. Scale bar, 100 μm. c, Cell surface area quantified from sections stained with WGA and analyzed by two-tailed Student’s t-test. Error bars denote the mean + /- s.e.m. n = 3 hearts per group. d, Lung sections of control and Kdm8 mutants at 4 and 6 months of age stained with H&E. Arrows point to areas of accumulated alveolar fluid. Scale bar = 100 μm. e, Alveolar area per 0.1 mm² in lung sections Error bars denote the mean + /- s.d. Data was analyzed by two-way ANOVA with Sidak correction. n = 3 4-month-old and 2 6-month-old lungs of controls, and 2 4-month-old and 2 6-month-old lungs of mutant mice.