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. 2023 Jan 30;2(2):112–125. doi: 10.1038/s44161-022-00208-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a. Dotplot displaying average expression of genes describing the different dendritic cell and macrophage clusters. DC-M indicates myeloid-derived dendritic cell (DC); DC-P indicates plasmacytoid DC; M-PROL indicates proliferating macrophages; M-Inf indicates inflammatory macrophage; M-TREM2 indicates TREM2hi macrophages. b. Heatmaps displaying outgoing (Ligand) and incoming (Receptor) signalling patterns of pathways describing potential ligand-receptor interactions. Scale above heatmap indicates the relative signalling strength of a cell cluster based on all signalling pathways displayed in the heatmap. Grey bars right of the heatmap show the total signalling strength of a pathway in all cell clusters. The relative signalling strength indicated by ranging color from white (low) to green (high). All cells included in these graphs originate from the plaque.