Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 30;2(2):112–125. doi: 10.1038/s44161-022-00208-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a, Atherosclerosis and PSA CD4⁺ T cells of PBMC, plaque and SF projected on an atherosclerosis CD4⁺ T cell reference UMAP (rUMAP). b, Atherosclerosis and PSA CD8⁺ T cells of PBMC, plaque and SF projected on an atherosclerosis CD8⁺ T cells rUMAP. c, rUMAP projecting clonal expansion levels of CD4⁺ T cells in atherosclerosis and PSA. d, Quantification of clonal expansion levels of CD4⁺ T cells in atherosclerosis, split over PBMC and tissue. e, rUMAP projecting clonal expansion levels of CD8⁺ T cells in atherosclerosis and PSA. f, Bar plot displaying quantification of clonal expansion levels of CD8⁺ T cells in atherosclerosis, split over PBMC and tissue. g, rUMAP projecting tissue enrichment scores of clonotypes in CD4⁺ T cells of atherosclerosis and PSA. h, Bar plot with quantification of tissue enrichment scores of CD4⁺ T cells in atherosclerosis and PSA, split by PBMC and tissue. i, rUMAP projecting tissue enrichment scores of clonotypes in CD8⁺ T cells of atherosclerosis and PSA. j, Quantification of tissue enrichment scores of CD8⁺ T cells in atherosclerosis and PSA, split by PBMC and tissue. k–n, Dot plots with average expression of genes characterizing the genes underlying the overlap between atherosclerosis and PSA in CD4⁺ T_reg cells (C5, k) and T_eff cells (C3, l) and in CD8⁺ T_eff cells (C3, m; C5, n). Clonotype expansion levels: Single (one occurrence), Small (≤0.1%), Medium (>0.1% and ≤1%), Large (>1% and ≤10%) and Hyperexpanded (>10%), percentage of, respectively, CD4⁺ and CD8⁺ T cells. Tissue enrichment scores: Tissue-enriched (frequency expanded clone higher in tissue versus PBMC), Single (one occurrence), Unenriched (frequency expanded clone similar in PBMC versus tissue) and PBMC-enriched (frequency expanded clone higher in PBMC versus tissue).