Table 1. A literature review of published cases with GCA treated with radiation therapy spanning from 1987 to 2019.
GCA: giant condyloma acuminata, HPV: human papillomavirus, 5FU: fluorouracil, SCC: squamous cell carcinoma, APR: abdominoperineal resection
| First Author/Pub Year | Gender | Age | HPV/HIV | Therapy | Fractions | Follow-Up | Recurrence | Additional Therapy | Pathology |
| Butler, 1987 [18] | Male | 40 | N/A | Definitive Radiotherapy, 5FU, mitomycin | 45Gy (28 fractions over 44d) | 32w | No | Diverting colostomy, surgical excisions | GCA w/ marked acanthosis, hyperkeratosis, and papillomatosis with well-differentiated in situ and invasive SCC |
| Hyacinthe, 1998 [23] | Male | 60 | HPV+ (6/11/16/18/31/33/35) | Radiotherapy, 5FU, mitomycin-C, posterior pelvic exenteration | 46.8Gy (26 fractions over 46d) | 2y | No | No | GCA with SCC transformation |
| Sobrado, 2000 [24] | Male | 42 | N/A | Definitive Radiation therapy | 45 Gy (28 fractions) during additional radiation therapy | 20mo | No | PRIOR to Radiation Therapy: Sigmoidostomy, bleomycin, topical podophyllin (recurrence in <30d) | |
| Dolanc, 2002 [25] | Female | 56 | HPV+ (6/11) | Radiotherapy, APR (Abdominoperineal Resection) | 50Gy | No | SCC arising in GCA w/ clear resection margins | ||
| Chao, 2005 [26] | Male | 57 | HIV- | Radiotherapy, 5FU, mitomycin | 50.4Gy to primary tumor, 45Gy to perirectal LN, 36Gy to inguinal LN | 1y | No | No | |
| Tytherleigh, 2006 [27] | Male | 40 | HIV+ | chemoradiation, APR (Abdominoperineal Resection) | 12mo | Yes, patient passed | N/A | GCA | |
| Male | 51 | HIV+ | chemoradiation, APR (Abdominoperineal Resection) | 5y | No | N/A | GCA | ||
| Armstrong, 2009 [28] | Male | 46 | HIV-, HPV+ (6/11) | Unsuccessful APR, chemoradiotherapy | 34mo | No | No | GCA | |
| Handisurya, 2009 [29] | Male | 45 | HIV+, HPV+ (6/11) | Surgical intervention | 60Gy (additional radiation therapy) | 6mo | Yes | Palliative surgery and chemoradiotherapy | GCA differentiating into invasive SCC |
| Haque, 2009 [30] | Male | 38 | HIV- | Definitive Radiotherapy, 5FU, mitomycin | 54Gy (30 fractions) | 6mo | No | PRIOR to Radiation Therapy: Two Surgical excisions (recurrence in <5mo) | GCA (Buschke-Lewenstein tumor-type) w/ focal transformation to verrucous carcinoma |
| Indinnimeo, 2013 [21] | Male | 43 | HIV+, HPV+ (6) | Radiotherapy, 5FU, mitomycin-C | 45Gy (28 fractions) to the pelvis plus a boost with 14.40Gy (1.8Gy/fr) to the primary tumor | 3y | No | EUS and high-resolution anoscopy (HRA) | GCA with SCC transformation |
| Shenoy, 2019 [31] | Male | 70 | HIV-, HPV+ | Radiotherapy, 5FU, mitomycin | 46Gy (30 fractions) | 3y | No | No | GCA, SCC of the anus |
| Male | 58 | HIV+, HPV+ | Radiotherapy, 5FU, mitomycin, diverting sigmoid colostomy | 46Gy (30 fractions) | 3mo | Yes | No | GCA, SCC of the anus |