Follow-up ordering of ECBL compounds after successful fragment screening campaigns using EU-OS FBS.

Project/target	Technique	ECBL compounds requested	ECBL binders identified	Hit rate (%)
Nsp3 macrodomain of SARS-CoV-2	X-ray crystallography	20	0 crystal-bound compounds at 1 mM	0.0%
Endothiapepsin	X-ray crystallography	20	2 (as determined by POLDER maps)	10.0%
Antibiotics E. coli enzyme	Small-angle X-ray scattering	51	0	0.0%
FabF/infectious diseases	Bio-layer interferometry	147	7 with KD < 100 μM	4.8%