Figure 4. Glial depletion triggers morphological changes in Paneth cells.

A) Representative images of UEA-I staining of Paneth cell granules in the small intestine of Cre⁻ and Cre⁺ mice (observed in at least 3 mice per genotype). Scale bar = 10μm.

B) Representative transmission electron microscopy images of Paneth cells (n = 2 mice per genotype from independent cohorts). Paneth cells in Cre⁺ mice are globular, exhibit loss of polarity, and have heterogeneous granules (PG). L, Lumen of the intestinal crypts; LP, lamina propria. Scale bar = 3μm.