Table 2.
Donor Characteristics by Contributing Institution
| Characteristic | Columbia N=105 |
Emory N=156 |
Mayo N=331 |
MSSM N=88 |
Rush N=228 |
|---|---|---|---|---|---|
| Female sex, N (%) | 72 (69%) | 89 (57%) | 166 (50%) | 49 (56%) | 160 (70%) |
| Age at death* in years, median (range) | 84.0 (51–90+) |
73.5 (20–90+) |
80.5 (20–90+) |
82.5 (62–90+) |
86.8 (54–90+) |
| Race†, N (%) | |||||
| Black or African American | 35 (33%) | 75 (48%) | 53 (16%) | 31 (35%) | 116 (51%) |
| Non-Hispanic White | 1 (1%) | 76 (49%) | 96 (29%) | 30 (34%) | 49 (21%) |
| Other | 68 (65%) | 5 (3%) | 182 (55%) | 27 (31%) | 44 (19%) |
| Asian | 1 (1%) | 0 | 0 | 0 | 11 (5%) |
| American Indian or Alaska Native | 0 | 0 | 0 | 0 | 5 (2%) |
| Missing or unknown | 0 | 0 | 0 | 0 | 3 (1%) |
| Hispanic ethnicity‡, N (%) | 69 (66%) | 5 (3%) | 182 (55%) | 27 (31%) | 52 (23%) |
| APOE genotype, N (%) | |||||
| ε2ε2 | 0 | 1 (1%) | 0 | 1 (1%) | 0 |
| ε2ε3 | 6 (6%) | 8 (5%) | 22 (7%) | 9 (10%) | 20 (9%) |
| ε2ε4 | 5 (5%) | 4 (3%) | 7 (2%) | 3 (3%) | 8 (4%) |
| ε3ε3 | 31 (30%) | 52 (33%) | 184 (56%) | 43 (49%) | 112 (49%) |
| ε3ε4 | 23 (22%) | 47 (30%) | 98 (30%) | 29 (33%) | 47 (21%) |
| ε4ε4 | 6 (6%) | 19 (12%) | 20 (6%) | 3 (3%) | 16 (7%) |
| Missing or unknown | 34 (32%) | 25 (16%) | 0 | 0 | 25 (11%) |
| Thal Phase, N (%) | |||||
| None | NA | 34 (22%) | 46 (14%) | NA | 22 (10%) |
| Phase 1 | NA | 3 (2%) | 13 (4%) | NA | 28 (12%) |
| Phase 2 | NA | 11 (7%) | 16 (5%) | NA | 10 (4%) |
| Phase 3 | NA | 7 (4%) | 20 (6%) | NA | 51 (22%) |
| Phase 4 | NA | 15 (10%) | 23 (7%) | NA | 29 (13%) |
| Phase 5 | NA | 51 (33%) | 131 (40%) | NA | 50 (22%) |
| Missing or unknown | NA | 35 (22%) | 82 (25%) | NA | 38 (17%) |
| CERAD, N (%) | |||||
| None/No AD/C0 | 19 (18%) | 64 (41%) | NA | 18 (20%) | 54 (24%) |
| Sparse/Possible/C1 | 15 (14%) | 1 (1%) | NA | 11 (12%) | 20 (9%) |
| Moderate/Probable/C2 | 20 (19%) | 6 (4%) | NA | 11 (12%) | 62 (27%) |
| Frequent/Definite/C3 | 49 (47%) | 83 (53%) | NA | 47 (53%) | 92 (40%) |
| Missing or unknown | 2 (2%) | 2 (1%) | NA | 1 (1%) | 0 |
| Braak stage, N (%) | |||||
| None | 2 (2%) | 21 (13%) | 15 (5%) | 4 (5%) | 8 (4%) |
| I | 1 (1%) | 27 (17%) | 27 (8%) | 3 (3%) | 14 (6%) |
| II | 4 (4%) | 14 (9%) | 41 (12%) | 11 (12%) | 21 (9%) |
| III | 11 (10%) | 14 (9%) | 58 (18%) | 7 (8%) | 37 (16%) |
| IV | 15 (14%) | 9 (6%) | 23 (7%) | 13 (15%) | 76 (33%) |
| V | 16 (15%) | 20 (13%) | 62 (19%) | 10 (11%) | 56 (25%) |
| VI | 52 (50%) | 49 (31%) | 100 (30%) | 35 (40%) | 16 (7%) |
| Missing or unknown | 4 (4%) | 2 (1%) | 5 (2%) | 5 (6%) | 0 |
*
Age at death was reported as 90+ for all individuals over 89 years old.
†
Self-reported race. The ‘other’ category stood in for individuals who might have reported themselves to be of Hispanic or Latinx ethnicity within a race category (this information is also captured in the Hispanic Ethnicity variable).
‡
Hispanic Ethnicity was captured as a TRUE/FALSE variable. Individuals of any self-reported race could report Hispanic Ethnicity = TRUE.
NA = Not applicable