Figure 3. Association of Functional Pathways with Recurrence Biomarkers.

(A) depicts the correlation between z-score normalized KEGG Level 3 bacterial pathways (presented in rows) of the recurrence-associated taxa (displayed in columns). The color of the column strip indicates the direction of association of the bacteria with recurrence (red for positive association and green for negative). The color of the row strip indicates the category (KEGG Level 2) of the functional pathway. The color of each cell represents the level of correlation. Functions are included only if they have a correlation FDR<0.0001 for a minimum of five recurrence-associated taxa.

(B) exclusively displays Carbohydrate metabolism pathways derived from (A).

(C) presents carbohydrate-associated pathways significantly correlated with recurrence in the North American region (no significant correlations in other regions), accounting for factors: age, sex, tumor stage, BRAF mutation and study arm. Y-axis of figure C represents the normalized z-score of the pathways.