Fig. 4 ∣. Predictive performance on gene expression and relationship between transcriptomic impact and cell growth.

a, AUC for CNN and XGBoost models with different sets of input features in scCERES. Statistically significant p-values from paired t-tests are listed above the bars. n.s.: not significant (i.e., p > 0.05). b, Density plot illustrating the distribution of FDR-adjusted p-values for the two groups of gRNAs, based on their observed impact (significant or insignificant) on cell fitness. c, Histogram illustrating the distribution of the number of genes significantly influenced by a gRNA, separately for the two groups of gRNAs, again based on their impact on cell fitness.