Table 1:
Parameter values from literature, calibration, and estimation. Here, aindicates that parameters value used to clear the infection scenario.
| Parameters | Description | Values | Units | Source |
|---|---|---|---|---|
| k | Drug absorption rate into plasma | 0.44 | hr −1 | Erwin et al.,20206 |
| β | Drug conversion factor into plasma | 0.0016 | μgmg−1·kgmL−1 | estimated |
| α | Net drug transfer rate in colon | 0.16 | hr −1 | estimated |
| υ | Elimination of drug from colon | 0.53 | hr −1 | estimated |
| σ | E. coli growth rate | 0.28 | hr −1 | estimated |
| N emax | Maximum bacteria (E. coli) concentration | 484577 | CFU s g −1 | estimated |
| C s50 | Fifty percent of sensitive bacteria (E. coli) killing effect | 0.25 | μgmL −1 | Liu et al.,202127 |
| C r50 | Fifty percent of bacteria (E. coli) above ECOFF bacteria killing effect | 0.471 | μgmL −1 | calibrated |
| d | Death rate of E. coli | 1.01 | hr −1 | calibrated |
| c | Fitness cost of E. coli | 0.05 | calibrated | |
| γ | Net drug transfer rate in lung | 0.16 | hr −1 | estimated |
| λ | P. multocida growth rate | 0.25 | hr −1 | calibrated |
| N mmax | Maximum bacteria (P. multocida) concentration | 512861 | CFU s g −1 | calibrated |
| L s50 | Fifty percent of sensitive bacteria (P. multocida) killing effect | 0.016 | μgmL −1 | Bello et al.,201919 |
| L r50 | Fifty percent of bacteria (P. multocida) above ECOFF bacteria killing effect | 0.125 | μgmL −1 | Bello et al.,201919 |
| δ | Elimination of drug from lung | 0.24 | hr −1 | estimated |
| η | Death rate of P. multocida | 0.40 | hr −1 | calibrated |
| p | Fitness cost of P. multocida | 0.05, 0.10a | calibrated | |
| ϕ | Immunological death rate | 0.14, 0.22a | hr −1 | calibrated |