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The immunological consequences of tumor cell infection by NDV. a The tumor vaccine ATV-NDV is produced by coincubation of 107 200-Gy irradiated tumor cells with 32 HU of NDV Ulster for 1 h at 37°C. b After intradermal application of the vaccine, virus replication occurs in situ and leads within 24–48 h in the skin to delayed-type hypersensitivity (DTH) reactivity. This may involve distinct innate (4–6) and adaptive (1–3) immune mechanisms as analyzed in vitro.
