Table 1.
Representative example | IFN-α (pg/ml)a | |
---|---|---|
Normal cells (adherent PBMCs)b | Tumor cells (MCF-7)c | |
+UV-inactivated NDV Ulster | 86,431 | <10 |
+Live NDV Ulster | 77,210 | 55 |
Effects | Independent on viral replication | Dependent on viral replication |
IFN-α titers | High | Low |
aCells (PBMCs or MCF-7) were coincubated for 3 days with 60 HU/107 cells of either live or UV-inactivated NDV, and then supernatants were tested by ELISA for IFN-α content
bThe major cell type producing IFN-α in PBMCs is the NIPC
cA human breast carcinoma cell line