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. 2024 Apr 24;19(4):e0300544. doi: 10.1371/journal.pone.0300544

Fig 10. The appetite suppressant effects of tesofensine and 5-HTP/CB is not due to taste aversion.

Fig 10

A. The graph plots the average 1-hour sucrose intake during baseline sessions. On day 7 (D7), drugs were administered before giving access to sucrose. A dose-dependent intake suppression can be seen. Finally, on day 8 (D8), intake was observed the day after treatment. 5-HTP/CB suppressed acute sucrose intake on day 7 (D7), but consumption returned to baseline levels on day 8 (D8). Bar plots show acute sucrose intake (1 hour) for control rats (vehicle injection) and treated rats (different doses of 5-HTP/CB). Each dose was tested once in a new set of naïve rats (n = 6 rats per group). Note that 5-HTP/CB induced a dose-dependent decrease in sucrose intake. BL = baseline sucrose intake. B. Same convention as panel “A” but for tesofensine. n = number of rats, open data points represent each rat. One-way ANOVA (A-B).* p<0.05 significantly different from BL.