Fig 11. Tesofensine did not affect performance of rats in a sucrose detection task.

A. Rats were trained to lick a central spout that dispensed the stimulus a drop of water or solutions of sucrose. To obtain a reward (3 drops of water), rats had to choose between two lateral spouts. B. Upper panel shows the number of trials, and the lower panel the correct performance across the baseline, tesofensine treatment, and post-tesofensine days. There were no significant differences in the percent correct, the trials per session, or the total volume consumed between these periods, except for an overall decrease in the number of trials during the baseline period as the rat re-learned the task. The gray rectangle depicts days of tesofensine administration C. Plots of high sucrose responses as a function of sucrose concentration. The psychometric curves for the sucrose detection task also did not differ significantly between the baseline, tesofensine, and post-tesofensine periods. These findings suggest that tesofensine does not affect performance in the sucrose detection task in rats. The x-axis is scaled logarithmically, and the data is represented as mean ± SEM.