Table 2.

Frequency, incidence rate, and hazard ratio for having a hospital contact for anxiety, ADHD, or depression or having a dispensed prescription for antidepressants or methylphenidate in the years after IBD diagnosis or index date

	IBD		Crohn's disease		Ulcerative colitis
	IR/1,000 PY	HR (95% CI)	IR/1,000 PY	HR (95% CI)	IR/1,000 PY	HR (95% CI)
Depression
References	3.18	1 (ref)	3.10	1 (ref)	3.25	1 (ref)
IBD	4.76	1.50 (1.26–1.80)	5.35	1.73 (1.35–2.22)	4.22	1.30 (1.01–1.69)
Anxiety
References	1.79	1 (ref)	1.78	1 (ref)	1.81	1 (ref)
IBD	2.05	1.14 (0.88–1.49)	2.08	1.17 (0.80–1.71)	2.02	1.12 (0.77–1.61)
ADHD
References	1.67	1 (ref)	1.72	1 (ref)	1.64	1 (ref)
IBD	1.29	0.77 (0.56–1.06)	1.57	0.92 (0.60–1.40)	1.03	0.63 (0.39–1.03)
Antidepressants
References	10.29	1 (ref)	10.07	1 (ref)	10.49	1 (ref)
IBD	15.71	1.54 (1.39–1.71)	15.85	1.59 (1.37–1.84)	15.58	1.50 (1.30–1.73)
Methylphenidate
References	2.49	1 (ref)	2.29	1 (ref)	2.64	1 (ref)
IBD	1.87	0.75 (0.58–0.98)	2.08	0.90 (0.62–1.31)	1.67	0.63 (0.43–0.93)

See Supplementary Table 1, http://links.lww.com/CTG/B37 for event numbers and total numbers of person years.

ADHD, attention-deficit/hyperactivity disorder; CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease; IR, incidence rate; PY, person years.