Table 5.
The impact of SPINK1 mutations on adverse pregnancy outcomes (n = 132)
| Comparison of characteristics | Univariate analyses | Multivariate analyses | ||||
| Patients with adverse pregnancy outcomes (n = 31) | Patients without adverse pregnancy outcomes (n = 101) | OR (95% CI) | P | OR (95% CI) | P | |
| Smoking history, n (%) | 1 (3.2) | 2 (2.0) | 1.65 (0.15–18.84) | 0.687 | ||
| Alcohol use, n (%) | 1 (3.2) | 1 (1.0) | 3.33 (0.20–54.91) | 0.400 | ||
| Age at first pregnancy, yr (IQR) | 25.0 (23.0–28.0) | 24.0 (22.0–27.8) | 1.09 (0.97–1.22) | 0.136 | ||
| Age at first delivery, yr (IQR) | 25.0 (23.0–28.0) | 24.0 (22.0–27.8) | 1.11 (0.99–1.24) | 0.082 | ||
| Onset symptoms, n (%) | ||||||
| Pain | 11 (35.5) | 33 (32.7) | Reference | |||
| AP | 14 (45.2) | 46 (45.5) | 0.91 (0.37–2.26) | 0.844 | ||
| Diabetes | 4 (12.9) | 8 (7.9) | 1.50 (0.38–5.97) | 0.565 | ||
| Steatorrhea | 1 (3.2) | 7 (6.9) | 0.43 (0.05–3.88) | 0.451 | ||
| Asymptomatic | 1 (3.2) | 7 (6.9) | 0.43 (0.05–3.88) | 0.451 | ||
| Etiology of CP, n (%) | ||||||
| Idiopathic | 24 (77.4) | 84 (83.2) | Reference | |||
| Alcoholic | 2 (6.5) | 2 (2.0) | 3.50 (0.47–26.17) | 0.222 | ||
| Hereditary | 1 (3.2) | 1 (1.0) | 3.50 (0.21–58.06) | 0.382 | ||
| Othersa | 4 (12.9) | 14 (13.9) | 1.00 (0.30–3.32) | 1.000 | ||
| SPINK1 mutations, n (%) | 22 (71.0) | 45 (44.6) | 3.04 (1.28–7.26) | 0.012 | 2.60 (1.06–6.37) | 0.037 |
| Acute pain attack during pregnancy, n (%) | 8 (25.8) | 5 (5.0) | 6.68 (2.00–22.32) | 0.002 | 5.50 (1.60–18.92) | 0.007 |
AP, acute pancreatitis; CI, confidence interval; CP, chronic pancreatitis; IQR, interquartile range; OR, odds ratio.
a
Other etiology of CP includes abnormal anatomy of pancreatic duct and trauma.