Table 3.

Multiple logistic regressions using plasma NGAL (top) or NGAL⁺ PBMC subpopulations (bottom) to predict CP

	Odds ratio	95% CI	P value	AUC
Plasma NGAL
Control vs CP				0.874****
Intercept	5.52	0.20–170.4	0.316
NGAL (1 ng/mL)	1.05	1.02–1.08	<0.001
Sex (male)	0.63	0.20–1.85	0.405
Age (yr)	1.01	0.97–1.05	0.809
BMI (kg/m2)	0.87	0.77–0.96	0.012
Smoking (never)	0.14	0.04–0.38	<0.001
AP/RAP vs CP				0.819****
Intercept	0.56	0.03–10.5	0.703
NGAL (1 ng/mL)	1.04	1.02–1.07	<0.001
Sex (male)	0.89	0.35–2.27	0.809
Age (yr)	1.03	1.0–1.07	0.096
BMI (kg/m2)	0.87	0.78–0.95	0.003
Smoking (never)	0.42	0.16–1.05	0.069
NGAL+ PBMCs
Control vs CP				0.950****
Intercept	10.39	0.002–93833	0.585
CD8+ central memory T cells	1.59	1.13–2.82	0.033
CD8+ effector T cells	0.98	0.89–1.08	0.750
Naive CD4+ T cells	0.95	0.85–1.04	0.273
Memory resting B cells	0.83	0.60–0.96	0.137
Myeloid dendritic cells	0.94	0.82–1.05	0.298
AP/RAP vs CP				0.941****
Intercept	10.64	0.001–645744	0.631
CD8+ central memory T cells	1.63	1.14–3.15	0.051
CD8+ effector T cells	1.06	0.94–1.22	0.392
Naive CD4+ T cells	1.04	0.92–1.19	0.565
Memory resting B cells	0.90	0.65–1.19	0.447
Myeloid dendritic cells	0.88	0.75–0.98	0.044

PROCEED study NGAL⁺ PBMC subpopulations that were significantly different between CP and either control or AP/RAP were considered.

AP, acute pancreatitis; BMI, body mass index; CP, chronic pancreatitis; NGAL, neutrophil gelatinase-associated lipocalin; PBMC, peripheral blood mononuclear cell; RAP, recurrent acute pancreatitis.

****ROC AUC P < 0.0001.